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Allele : Ptch1<tm1Mps> patched 1; targeted mutation 1, Matthew P Scott

Primary Identifier  MGI:1857447 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Ptch1
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Ptc1<->,
  • Ptch-,
  • LacZ/Ptc,
  • Ptch1-,
  • Ptc1<->,
  • Ptch<KO1>,
  • Ptch<lacZ>,
  • Ptc1-lacZ,
  • Ptch<lacZ>,
  • Ptc1<lzki>,
  • Ptch-,
  • Ptc<n>,
  • ptc-,
  • Ptch1-lacZ,
  • LacZ/Ptc,
  • ptc-,
  • Ptc<lacZ>,
  • Ptc1-lacZ,
  • Ptch<KO1>,
  • ptc-lacZ,
  • Ptc1<lzki>,
  • Ptc<n>,
  • Ptch1-,
  • ptc-lacZ,
  • Ptc<lacZ>,
  • Ptch1-lacZ
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

341 Publication categories