| First Author | Hsu CC | Year | 2018 |
| Journal | Virology | Volume | 515 |
| Pages | 123-133 | PubMed ID | 29287229 |
| Mgi Jnum | J:271907 | Mgi Id | MGI:6282288 |
| Doi | 10.1016/j.virol.2017.12.013 | Citation | Hsu CC, et al. (2018) Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice. Virology 515:123-133 |
| abstractText | Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1(-/-) hematopoietic cells and Stat1(-/-) stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1(-/-) B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild-type STAT1 is required to protect B cell development during infection. |
