| First Author | Nozad Charoudeh H | Year | 2010 |
| Journal | Blood | Volume | 116 |
| Issue | 2 | Pages | 183-92 |
| PubMed ID | 20421450 | Mgi Jnum | J:162802 |
| Mgi Id | MGI:4819909 | Doi | 10.1182/blood-2009-10-247130 |
| Citation | Nozad Charoudeh H, et al. (2010) Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood 116(2):183-92 |
| abstractText | Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. |
