| First Author | Uchida J | Year | 1999 |
| Journal | Science | Volume | 286 |
| Issue | 5438 | Pages | 300-3 |
| PubMed ID | 10514374 | Mgi Jnum | J:328036 |
| Mgi Id | MGI:7328961 | Doi | 10.1126/science.286.5438.300 |
| Citation | Uchida J, et al. (1999) Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 286(5438):300-3 |
| abstractText | The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection. |
