| First Author | Cho S | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 2757 |
| PubMed ID | 30013024 | Mgi Jnum | J:266124 |
| Mgi Id | MGI:6208937 | Doi | 10.1038/s41467-018-05196-3 |
| Citation | Cho S, et al. (2018) Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun 9(1):2757 |
| abstractText | Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signaling pathway components in B cells; by contrast, loss of miR-146a in T cells does not alter humoral responses. However, specific deletion of both miR-146a and its paralog, miR-146b, in T cells increases Tfh cell numbers and enhanced GC reactions. Thus, our data reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b. Together, members of the miR-146 family serve as crucial molecular brakes to coordinately control GC reactions to generate protective humoral responses without eliciting unwanted autoimmunity. |
