| First Author | Montfort MJ | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 6 | Pages | 4084-90 |
| PubMed ID | 15356158 | Mgi Jnum | J:92749 |
| Mgi Id | MGI:3054468 | Doi | 10.4049/jimmunol.173.6.4084 |
| Citation | Montfort MJ, et al. (2004) The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40. J Immunol 173(6):4084-90 |
| abstractText | The immunologic requirements for generating long-lived protective CD8 T cell memory remain unclear. Memory CD8 populations generated in the absence of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and functional quality of memory CD8 populations. To ascertain the role of CD40 in such direct T cell interactions, we investigated CD8 T cell responses in CD40-/- mice after infection with Listeria monocytogenes, an intracellular bacterium that induces APC activation and thus priming of CD8 T cells independently of CD4 Th cell help through CD40. In this study we show that memory CD8 T cells generated in CD40-deficient mice show in vivo cytotoxicity and cytokine production equivalent to CD8 memory T cells from wild-type mice. Upon secondary Listeria infection, CD40-/- memory CD8 T cells expand to greater numbers than seen in wild-type mice. These results indicate that CD40 ligation on CD8 T cells, although reportedly a part of CD8 T cell memory development in an H-Y-directed response, is not needed for the development of functional memory CD8 T cell populations after Listeria infection. |
