| First Author | Naganawa T | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 339 |
| Issue | 2 | Pages | 490-8 |
| PubMed ID | 16298332 | Mgi Jnum | J:103985 |
| Mgi Id | MGI:3610941 | Doi | 10.1016/j.bbrc.2005.10.215 |
| Citation | Naganawa T, et al. (2006) In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice. Biochem Biophys Res Commun 339(2):490-8 |
| abstractText | We previously reported that deletion of the Fgf2 gene (Fgf2-/-) resulted in decreased bone mass in adult mice. This study examines the effect of haplo-insuffiency (Fgf2+/-) on bone loss in vertebrae from these mutant mice. Fgf2+/+ mice attained peak bone mass at 8-9 months of age. In contrast BMD was significantly reduced in vertebrae from adult (8-9) Fgf2+/- mice. Exogenous FGF-2 rescued reduced bone nodule formation in Fgf2+/- and Fgf2-/- cultures. Runx2 mRNA was reduced in cultures from Fgf2+/- and Fgf2-/- mice. FGF receptor2 mRNA and protein were markedly reduced in Fgf2+/- and Fgf2-/- mice. Decreased bone formation in Fgf2 mutant mice may correlate with impaired FGFR signaling, decreased Runx2 gene expression. |
