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Allele : Adra2a<tm1Lel> adrenergic receptor, alpha 2a; targeted mutation 1, Lee E Limbird

Primary Identifier  MGI:1857459 Allele Type  Targeted
Attribute String  Null/knockout Gene  Adra2a
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  Point mutations were introduced to alter the codon at position 79 from one encoding aspartic acid to one encoding asparagine. RNase protection assays indicated that normal levels of transcript were produced from this allele, but binding assays indicated that no functional protein was present in isolated brain membranes of homozygous mice.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • D79N,
  • alpha2A-AR<D79N>,
  • D79N,
  • alpha2A-AR<D79N>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

19 Publication categories