| First Author | Hampton LL | Year | 1998 |
| Journal | Proc Natl Acad Sci U S A | Volume | 95 |
| Issue | 6 | Pages | 3188-92 |
| PubMed ID | 9501238 | Mgi Jnum | J:46897 |
| Mgi Id | MGI:1202207 | Doi | 10.1073/pnas.95.6.3188 |
| Citation | Hampton LL, et al. (1998) Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. Proc Natl Acad Sci U S A 95(6):3188-92 |
| abstractText | The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven- transmembrane G protein coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome- linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP- R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety. |
