| First Author | Zheng L | Year | 1995 |
| Journal | Nature | Volume | 377 |
| Issue | 6547 | Pages | 348-51 |
| PubMed ID | 7566090 | Mgi Jnum | J:28944 |
| Mgi Id | MGI:76481 | Doi | 10.1038/377348a0 |
| Citation | Zheng L, et al. (1995) Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377(6547):348-51 |
| abstractText | T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively. However, peripheral T-cell deletion takes place in lpr mice, and autoimmune syndromes occur in mouse strains without Fas or FasL defects. Here we show that tumour necrosis factor (TNF) can mediate mature T-cell receptor-induced apoptosis through the p75 TNF receptor. Blockage of both TNF and FasL is required to abrogate T-cell death and TNF mediates the death of most CD8+ T cells, whereas FasL mediates the death of most CD4+ T cells. Our results suggest that autoregulatory apoptosis of the mature T cells can occur by two distinct molecular mechanisms. |
