| First Author | Page DM | Year | 1998 |
| Journal | J Immunol | Volume | 160 |
| Issue | 1 | Pages | 120-33 |
| PubMed ID | 9551964 | Mgi Jnum | J:110946 |
| Mgi Id | MGI:3652439 | Doi | 10.4049/jimmunol.160.1.120 |
| Citation | Page DM, et al. (1998) TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol 160(1):120-33 |
| abstractText | Central tolerance depends upon Ag-mediated cell death in developing thymocytes. However, the mechanism of induced death is poorly understood. Among the known death-inducing proteins, TNF was previously found to be constitutively expressed in the thymus. The role of TNF in thymocyte negative selection was therefore investigated using TNF receptor (TNFR)-deficient mice containing a TCR transgene. TNFR-deficient mice displayed aberrant negative selection in two models: an in vitro system in which APC are cultured with thymocytes, and a popular in vivo system in which mice are treated with anti-CD3 Abs. In contrast, TNFR-deficient mice displayed normal thymocyte deletion in two Ag-induced in vivo models of negative selection. Current models of negative selection and the role of TNFR family members in this process are discussed in light of these results. |
