|  Help  |  About  |  Contact Us

Publication : A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

First Author  Boege Y Year  2017
Journal  Cancer Cell Volume  32
Issue  3 Pages  342-359.e10
PubMed ID  28898696 Mgi Jnum  J:245569
Mgi Id  MGI:5919426 Doi  10.1016/j.ccell.2017.08.010
Citation  Boege Y, et al. (2017) A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell 32(3):342-359.e10
abstractText  Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLIP, and a kinase-dependent function of RIPK1. This platform requires a non-apoptotic function of caspase-8, but no caspase-3 or caspase-8 cleavage. It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

40 Bio Entities

0 Expression