| First Author | Chen LW | Year | 2003 |
| Journal | Nat Med | Volume | 9 |
| Issue | 5 | Pages | 575-81 |
| PubMed ID | 12692538 | Mgi Jnum | J:83313 |
| Mgi Id | MGI:2661007 | Doi | 10.1038/nm849 |
| Citation | Chen LW, et al. (2003) The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-81 |
| abstractText | We studied the role of NF-kappaB in acute inflammation caused by gut ischemia-reperfusion through selective ablation of IkappaB kinase (IKK)-beta, the catalytic subunit of IKK that is essential for NF-kappaB activation. Ablation of IKK-beta in enterocytes prevented the systemic inflammatory response, which culminates in multiple organ dysfunction syndrome (MODS) that is normally triggered by gut ischemia-reperfusion. IKK-beta removal from enterocytes, however, also resulted in severe apoptotic damage to the reperfused intestinal mucosa. These results show the dual function of the NF-kappaB system, which is responsible for both tissue protection and systemic inflammation, and underscore the caution that should be exerted in using NF-kappaB and IKK inhibitors. |
