| First Author | Choksi S | Year | 2011 |
| Journal | Mol Cell | Volume | 42 |
| Issue | 5 | Pages | 597-609 |
| PubMed ID | 21658601 | Mgi Jnum | J:173568 |
| Mgi Id | MGI:5014460 | Doi | 10.1016/j.molcel.2011.03.030 |
| Citation | Choksi S, et al. (2011) A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2. Mol Cell 42(5):597-609 |
| abstractText | The regulation of apoptosis is critical for controlling tissue homeostasis and preventing tumor formation and growth. Reactive oxygen species (ROS) generation plays a key role in such regulation. Here, we describe a HIF-1 target, Vasn/ATIA (anti-TNFalpha-induced apoptosis), which protects cells against TNFalpha- and hypoxia-induced apoptosis. Through the generation of ATIA knockout mice, we show that ATIA protects cells from apoptosis through regulating the function of the mitochondrial antioxidant, thioredoxin-2, and ROS generation. ATIA is highly expressed in human glioblastoma, and ATIA knockdown in glioblastoma cells renders them sensitive to hypoxia-induced apoptosis. Therefore, ATIA is not only a HIF-1 target that regulates mitochondrial redox pathways but also a potentially diagnostic marker and therapeutic target in human glioblastoma. |
