| First Author | Smiley ST | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5302 | Pages | 977-9 |
| PubMed ID | 9020080 | Mgi Jnum | J:47769 |
| Mgi Id | MGI:1306675 | Doi | 10.1126/science.275.5302.977 |
| Citation | Smiley ST, et al. (1997) Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275(5302):977-9 |
| abstractText | A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (TH2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical TH2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses. |
