| First Author | Hansen DS | Year | 2003 |
| Journal | Immunity | Volume | 18 |
| Issue | 3 | Pages | 391-402 |
| PubMed ID | 12648456 | Mgi Jnum | J:82493 |
| Mgi Id | MGI:2653406 | Doi | 10.1016/s1074-7613(03)00052-9 |
| Citation | Hansen DS, et al. (2003) Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18(3):391-402 |
| abstractText | NKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they rapidly produce high levels of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) and are therefore postulated to influence T(H)1/T(H)2 immune responses. The precise role of the CD1/NKT cell pathway in immune response to infection remains unclear. We show here that CD1d-restricted NKT cells from distinct genetic backgrounds differentially influence T(H)1/T(H)2 polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei ANKA/rodent model of cerebral malaria. The functional properties of CD1d-restricted NKT cells vary according to expression of loci of the natural killer complex (NKC) located on mouse chromosome 6, which is shown here to be a significant genetic determinant of murine malarial fatalities. |
