| First Author | Mulero MC | Year | 2013 |
| Journal | Cancer Cell | Volume | 24 |
| Issue | 2 | Pages | 151-66 |
| PubMed ID | 23850221 | Mgi Jnum | J:201834 |
| Mgi Id | MGI:5515848 | Doi | 10.1016/j.ccr.2013.06.003 |
| Citation | Mulero MC, et al. (2013) Chromatin-bound IkappaBalpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell 24(2):151-66 |
| abstractText | IkappaB proteins are the primary inhibitors of NF-kappaB. Here, we demonstrate that sumoylated and phosphorylated IkappaBalpha accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IkappaBalpha modulates Polycomb recruitment and imparts their competence to be activated by TNFalpha. Mutations in the Drosophila IkappaBalpha gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-kappaB. Oncogenic transformation of keratinocytes results in cytoplasmic IkappaBalpha translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IkappaBalpha was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation. |
