| First Author | Engleka KA | Year | 2007 |
| Journal | Dev Biol | Volume | 311 |
| Issue | 2 | Pages | 524-37 |
| PubMed ID | 17927973 | Mgi Jnum | J:127545 |
| Mgi Id | MGI:3763871 | Doi | 10.1016/j.ydbio.2007.08.057 |
| Citation | Engleka KA, et al. (2007) Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol 311(2):524-37 |
| abstractText | Menin is a nuclear protein encoded by a tumor suppressor gene that is mutated in humans with multiple endocrine neoplasia type 1 (MEN1). Menin functions as a component of a histone methyltransferase complex that regulates expression of target genes including the cell cycle inhibitor p27(kip1). Here, we show that menin plays a previously unappreciated and critical role in cranial neural crest. Tissue-specific inactivation of menin in Pax3- or Wnt1-expressing neural crest cells leads to perinatal death, cleft palate and other cranial bone defects, which are associated with a decrease in p27(kip1) expression. Deletion of menin in Pax3-expressing somite precursors also produces patterning defects of rib formation. Thus, menin functions in vivo during osteogenesis and is required for palatogenesis, skeletal rib formation and perinatal viability. |
