| First Author | Patel SC | Year | 1987 |
| Journal | Biochem Biophys Res Commun | Volume | 143 |
| Issue | 1 | Pages | 233-40 |
| PubMed ID | 3827919 | Mgi Jnum | J:8620 |
| Mgi Id | MGI:57085 | Doi | 10.1016/0006-291x(87)90655-3 |
| Citation | Patel SC, et al. (1987) Impaired cholesterol esterification in primary brain cultures of the lysosomal cholesterol storage disorder (LCSD) mouse mutant. Biochem Biophys Res Commun 143(1):233-40 |
| abstractText | Esterification of cholesterol was investigated in primary neuroglial cultures obtained from newborn lysosomal cholesterol storage disorder (LCSD) mouse mutants. An impairment in 3H-oleic acid incorporation into cholesteryl esters was demonstrated in cultures of homozygous LCSD brain. Primary cultures derived from other phenotypically normal pups of the carrier breeders esterified cholesterol at normal levels or at levels which were intermediary between normal and deficient indicating a phenotypic expression of the LCSD heterozygote genotype. These observations on LCSD mutant brain cells indicate that the defect in cholesterol esterification is closely related to the primary genetic defect and is expressed in neuroglial cells in culture. |
