| First Author | Kurihara Y | Year | 1994 |
| Journal | Nature | Volume | 368 |
| Issue | 6473 | Pages | 703-10 |
| PubMed ID | 8152482 | Mgi Jnum | J:17694 |
| Mgi Id | MGI:65725 | Doi | 10.1038/368703a0 |
| Citation | Kurihara Y, et al. (1994) Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1 [see comments]. Nature 368(6473):703-10 |
| abstractText | The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis. |
