| First Author | Tsapogas P | Year | 2011 |
| Journal | Blood | Volume | 118 |
| Issue | 5 | Pages | 1283-90 |
| PubMed ID | 21652681 | Mgi Jnum | J:176937 |
| Mgi Id | MGI:5293207 | Doi | 10.1182/blood-2011-01-332189 |
| Citation | Tsapogas P, et al. (2011) IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors. Blood 118(5):1283-90 |
| abstractText | Deficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors. |
