| First Author | Dias S | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 6 | Pages | 971-9 |
| PubMed ID | 15767371 | Mgi Jnum | J:97990 |
| Mgi Id | MGI:3576851 | Doi | 10.1084/jem.20042393 |
| Citation | Dias S, et al. (2005) Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med 201(6):971-9 |
| abstractText | Interleukin-7 (IL-7) promotes survival and expansion of lymphoid precursors. We show here that, in addition, IL-7 has a fundamental role, as early as the stage of the multipotent (B/T/NK) common lymphoid progenitor (CLP), in maintaining the B cell differentiation program open. CLPs generated in the absence of IL-7 have normal T/NK differentiation potential, but severely impaired B potential. Accordingly, CLPs from IL-7-deficient mice express lower amounts of early B cell factor (EBF) and Pax5 than wild-type CLPs, but similar amounts of GATA-3. Importantly, induced overexpression of EBF is sufficient to restore the B potential in these cells. These results indicate that IL-7 directs commitment of CLPs by modulating EBF expression. This is the first example of a cytokine influencing lymphoid lineage commitment in multipotent progenitors and highlights the relevance of the expression of a functional IL-7 receptor at the CLP stage. |
