| First Author | Dudley AT | Year | 1995 |
| Journal | Genes Dev | Volume | 9 |
| Issue | 22 | Pages | 2795-807 |
| PubMed ID | 7590254 | Mgi Jnum | J:30057 |
| Mgi Id | MGI:77579 | Doi | 10.1101/gad.9.22.2795 |
| Citation | Dudley AT, et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9(22):2795-2807 |
| abstractText | BMP-7/OP-1, a member of the transforming growth factor- beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development. |
