| First Author | Peichel CL | Year | 1996 |
| Journal | Genetics | Volume | 144 |
| Issue | 4 | Pages | 1757-67 |
| PubMed ID | 8978061 | Mgi Jnum | J:37225 |
| Mgi Id | MGI:84627 | Doi | 10.1093/genetics/144.4.1757 |
| Citation | Peichel CL, et al. (1996) Genetic and physical mapping of the mouse Ulnaless locus. Genetics 144(4):1757-67 |
| abstractText | The mouse Ulnaless locus is a semidominant mutation which displays defects in patterning along the proximal-distal and anterior-posterior axes of all four limbs. The first Ulnaless homozygotes have been generated, and they display a similar, though slightly more severe, limb phenotype than the heterozygotes. To create a refined genetic map of the Ulnaless region using molecular markers, four backcrosses segregating Ulnaless were established. A 0.4- cM interval containing the Ulnaless locus has been defined on mouse chromosome 2, which has identified Ulnaless as a possible allele of a Hoxd cluster gene(s). With this genetic map as a framework, a physical map of the Ulnaless region has been completed. Yeast artificial chromosomes covering this region have been isolated and ordered into a 2 Mb contig. Therefore, the region that must contain the Ulnaless locus has been defined and cloned, which will be invaluable for the identification of the molecular nature of the Ulnaless mutation. |
