| First Author | Roussarie JP | Year | 2007 |
| Journal | PLoS One | Volume | 2 |
| Issue | 12 | Pages | e1331 |
| PubMed ID | 18159229 | Mgi Jnum | J:129297 |
| Mgi Id | MGI:3768989 | Doi | 10.1371/journal.pone.0001331 |
| Citation | Roussarie JP, et al. (2007) Axon myelin transfer of a non-enveloped virus. PLoS One 2(12):e1331 |
| abstractText | We showed previously that Theiler's virus, a neurotropic non-enveloped picornavirus of mouse, traffics from the axon of infected neurons into the surrounding myelin. When this traffic is interrupted, as in the shiverer mouse which bears a mutation in the myelin basic protein gene, the virus is unable to persist in the central nervous system. In the present work, we used the Wld(s) mutant mouse, a strain in which axonal degeneration is considerably slowed down, to show that axon to myelin traffic takes place in the absence of axon degeneration. Our results suggest the existence of a mechanism of transfer of axonal cytoplasm into the myelin which Theiler's virus might exploit to ensure its persistence. |
