| First Author | Miller AJ | Year | 2008 |
| Journal | Nat Methods | Volume | 5 |
| Issue | 3 | Pages | 227-9 |
| PubMed ID | 18264106 | Mgi Jnum | J:204653 |
| Mgi Id | MGI:5538286 | Doi | 10.1038/nmeth.1183 |
| Citation | Miller AJ, et al. (2008) Tractable Cre-lox system for stochastic alteration of genes in mice. Nat Methods 5(3):227-9 |
| abstractText | We developed a cell division-activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cells surrounded by normal tissue, mimicking spontaneous cancer-causing mutations. This system should be particularly useful for delineating pathways of neoplasia, and determining the developmental and aging consequences of specific gene alterations. |
