| First Author | Cannon CM | Year | 2003 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 284 |
| Issue | 6 | Pages | R1384-8 |
| PubMed ID | 12736175 | Mgi Jnum | J:83905 |
| Mgi Id | MGI:2664062 | Doi | 10.1152/ajpregu.00689.2002 |
| Citation | Cannon CM, et al. (2003) Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokinin. Am J Physiol Regul Integr Comp Physiol 284(6):R1384-8 |
| abstractText | CCK octapeptide (CCK-8) is released by the gut in response to a meal and acts via CCK(A) receptors on vagal afferents to induce satiety. However, the central neural pathways by which peripheral CCK-8 affects feeding are poorly understood. In the present study, we tested the hypothesis that norepinephrine (NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta-hydroxylase (Dbh(-/-)), the enzyme responsible for synthesizing NE and epinephrine from dopamine. We found that Dbh(-/-) mice are as responsive to the satiating effects of CCK-8 as their normal littermates. |
