| First Author | Klein A | Year | 2005 |
| Journal | J Mol Med (Berl) | Volume | 83 |
| Issue | 5 | Pages | 362-76 |
| PubMed ID | 15662539 | Mgi Jnum | J:224966 |
| Mgi Id | MGI:5689800 | Doi | 10.1007/s00109-004-0625-1 |
| Citation | Klein A, et al. (2005) Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals. J Mol Med (Berl) 83(5):362-76 |
| abstractText | Microarray studies revealed that as a first hit the SV40 T/t antigen causes deregulation of 462 genes in mammary gland cells (ME cells) of WAP-SVT/t transgenic animals. The majority of deregulated genes are cell proliferation specific and Rb-E2F dependent, causing ME cell proliferation and gland hyperplasia but not breast cancer formation. In the breast tumor cells a further 207 genes are differentially expressed, most of them belonging to the cell communication category. In tissue culture breast tumor cells frequently switch off WAP-SVT/t transgene expression and regain the morphology and growth characteristics of normal ME cells, although the tumor-revertant cells are aneuploid and only 114 genes regain the expression level of normal ME cells. The profile of retransformants shows that only 38 deregulated genes are tumor-specific, and that none of them is considered to be a typical breast cancer gene. |
