| First Author | Boehme SA | Year | 1996 |
| Journal | J Immunol | Volume | 156 |
| Issue | 11 | Pages | 4075-8 |
| PubMed ID | 8666771 | Mgi Jnum | J:110825 |
| Mgi Id | MGI:3641366 | Doi | 10.4049/jimmunol.156.11.4075 |
| Citation | Boehme SA, et al. (1996) TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J Immunol 156(11):4075-8 |
| abstractText | The p53 protein plays an important role in various forms of thymocyte apoptosis, however its role in mature T lymphocyte death caused by TCR stimulation has not been examined. We demonstrate here that T cell blasts derived from mice containing a germ-line deficiency of the p53 tumor suppressor gene are susceptible to TCR-induced apoptosis to the same degree as wild-type T cells. TCR stimulation of both resting and proliferatingT cells results in up-regulated expression of the p53-induced genes Bax and p21, and the induction of these genes appears reduced in T cells that are deficient in p53. Thus, while activation of p53-dependent genes following TCR stimulation is defective in p53-/- T cells, there is no impairment in their ability to undergo apoptosis. These results suggest that TCR-mediated apoptosis of mature T cells takes place via a pathway that is independent of p53. |
