| First Author | Li Y | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 9 | Pages | e107589 |
| PubMed ID | 25208064 | Mgi Jnum | J:223417 |
| Mgi Id | MGI:5648790 | Doi | 10.1371/journal.pone.0107589 |
| Citation | Li Y, et al. (2014) Activation of Cre recombinase alone can induce complete tumor regression. PLoS One 9(9):e107589 |
| abstractText | The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53-/- mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors. |
