| First Author | Van Batavia J | Year | 2014 |
| Journal | Nat Cell Biol | Volume | 16 |
| Issue | 10 | Pages | 982-91, 1-5 |
| PubMed ID | 25218638 | Mgi Jnum | J:217711 |
| Mgi Id | MGI:5615349 | Doi | 10.1038/ncb3038 |
| Citation | Van Batavia J, et al. (2014) Bladder cancers arise from distinct urothelial sub-populations. Nat Cell Biol 16(10):982-91, 1-5 |
| abstractText | Bladder cancer is the sixth most common cancer in humans. This heterogeneous set of lesions including urothelial carcinoma (Uca) and squamous cell carcinoma (SCC) arise from the urothelium, a stratified epithelium composed of K5-expressing basal cells, intermediate cells and umbrella cells. Superficial Uca lesions are morphologically distinct and exhibit different clinical behaviours: carcinoma in situ (CIS) is a flat aggressive lesion, whereas papillary carcinomas are generally low-grade and non-invasive. Whether these distinct characteristics reflect different cell types of origin is unknown. Here we show using lineage tracing in a murine model of carcinogenesis that intermediate cells give rise primarily to papillary lesions, whereas K5-basal cells are likely progenitors of CIS, muscle-invasive lesions and SCC depending on the genetic background. Our results provide a cellular and genetic basis for the diversity in bladder cancer lesions and provide a possible explanation for their clinical and morphological differences. |
