| First Author | Katoh H | Year | 1989 |
| Journal | Mouse News Lett | Volume | 84 |
| Pages | 94-95 | Mgi Jnum | J:14257 |
| Mgi Id | MGI:62429 | Citation | Katoh H (1989) Semidominant short tail (TJic). Mouse News Lett 84:94-95 |
| abstractText | Full text of MNL contribution: Research News: b. Semidominant short tail (TJic). One male mouse with a short tail appeared in a litter (two females and one male) of the DTB strain in 1983. Family studies and preliminary mating experiments suggested that this mutant gene was expressed dominantly in the next generation. Since there was a possibility that the mutant gene would be the T locus gene located on chr. 17, three kinds of matings were carried out to confirm this: (1) short tail female and normal male, (2) normal female and short tail male, and (3) short tail female and short tail male. The first and second types of matings produced normal and short tail mice of both sexes in the same proportion. Ninety nine mice from 15 pairs consisted of 54 short tail mice and 45 normal tail mice. Average litter size was 6.6. On the other hand, four pairs of the third type of mating produced 18 mice (11 short tail and seven normal tail). Average litter size, 4.5, was significantly lower than that of the two former types of matings. Reduction in litter size was probably caused by death of mice homozygous for the mutant gene. In order to carry out a linkage study, DTB short tail (H-2b) was mated with the CTR strain (H-2k) with a normal tail. The Fl hybrids were backcrossed with CTR. Thirty six backcross progeny were classified into four groups: H-2b/k with short tail, H-2k/k with short tail, H-2b/k with normal tail, and H-2k/k with normal tail, and the ratio was 21:2:0:13. Two out of 36 mice were recombinants between the short tail gene and the H-2 gene. Distance of the two genes on chromosome 17 was calculated as 5.6 cM. These data strongly suggested that the short tail was caused by an autosomal semidominant gene closely linked to the H-2 locus. The mutant gene was named T-Jic. At the present, the B10 congenic strain for T-Jic is being bred by backcrossing to the C57BL/10ScSnJ strain. (H. Katoh) |
