| First Author | Degroot A | Year | 2005 |
| Journal | Behav Brain Res | Volume | 162 |
| Issue | 1 | Pages | 161-4 |
| PubMed ID | 15922076 | Mgi Jnum | J:98843 |
| Mgi Id | MGI:3580036 | Doi | 10.1016/j.bbr.2005.02.018 |
| Citation | Degroot A, et al. (2005) Genetic deletion of CB1 receptors improves non-associative learning. Behav Brain Res 162(1):161-4 |
| abstractText | Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 and M2/M4, but not M4, receptor knockout mice appeared to have an impaired ability to habituate, whereas CB1 receptor knockout mice showed enhanced habituation compared to wild-type animals. We conclude that CB1 receptor gene invalidation improves habituation tentatively through an increase in cholinergic neurotransmission. |
