| First Author | Cho C | Year | 1998 |
| Journal | Science | Volume | 281 |
| Issue | 5384 | Pages | 1857-9 |
| PubMed ID | 9743500 | Mgi Jnum | J:50040 |
| Mgi Id | MGI:1289774 | Doi | 10.1126/science.281.5384.1857 |
| Citation | Cho C, et al. (1998) Fertilization defects in sperm from mice lacking fertilin beta. Science 281(5384):1857-9 |
| abstractText | Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis. |
