| First Author | Park JM | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 3 | Pages | 319-29 |
| PubMed ID | 16169504 | Mgi Jnum | J:113273 |
| Mgi Id | MGI:3665341 | Doi | 10.1016/j.immuni.2005.08.010 |
| Citation | Park JM, et al. (2005) Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity 23(3):319-29 |
| abstractText | Certain microbes evade host innate immunity by killing activated macrophages with the help of virulence factors that target prosurvival pathways. For instance, infection of macrophages with the TLR4-activating bacterium Bacillus anthracis triggers an apoptotic response due to inhibition of p38 MAP kinase activation by the bacterial-produced lethal toxin. Other pathogens induce macrophage apoptosis by preventing activation of NF-kappaB, which depends on IkappaB kinase beta (IKKbeta). To better understand how p38 and NF-kappaB maintain macrophage survival, we searched for target genes whose products prevent TLR4-induced apoptosis and a p38-dependent transcription factor required for their induction. Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival. |
