| First Author | Masu Y | Year | 1993 |
| Journal | Nature | Volume | 365 |
| Issue | 6441 | Pages | 27-32 |
| PubMed ID | 8361533 | Mgi Jnum | J:15313 |
| Mgi Id | MGI:63440 | Doi | 10.1038/365027a0 |
| Citation | Masu Y, et al. (1993) Disruption of the CNTF gene results in motor neuron degeneration. Nature 365(6441):27-32 |
| abstractText | CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength. |
