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Publication : Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.

First Author  Gresle MM Year  2015
Journal  Glia Volume  63
Issue  6 Pages  1005-20
PubMed ID  25639936 Mgi Jnum  J:220854
Mgi Id  MGI:5636562 Doi  10.1002/glia.22798
Citation  Gresle MM, et al. (2015) Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor. Glia 63(6):1005-20
abstractText  In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC) survival, we utilized microarrays to characterize changes in OC gene expression after exposure to the cytokines neurotrophin3, insulin, or leukemia inhibitory factor (LIF) in vitro. We identified and validated the induction and secretion of the neuropeptide galanin in OCs, specifically in response to LIF. We next established that galanin is an OC survival factor and showed that autocrine or paracrine galanin secretion mediates LIF-induced OC survival in vitro. We also revealed that galanin is up-regulated in OCs in the cuprizone model of central demyelination, and that oligodendroglial galanin expression is significantly regulated by endogenous LIF in this context. We also showed that knock-out of galanin reduces OC survival and exacerbates callosal demyelination in the cuprizone model. These findings suggest a potential role for the use of galanin agonists in the treatment of human demyelinating diseases. GLIA 2015;63:1005-1020.
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