| First Author | Nakagawa Y | Year | 2016 |
| Journal | Sci Rep | Volume | 6 |
| Pages | 39182 | PubMed ID | 27982131 |
| Mgi Jnum | J:250182 | Mgi Id | MGI:6101558 |
| Doi | 10.1038/srep39182 | Citation | Nakagawa Y, et al. (2016) CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARalpha. Sci Rep 6:39182 |
| abstractText | CREB3L3 is involved in fatty acid oxidation and ketogenesis in a mutual manner with PPARalpha. To evaluate relative contribution, a combination of knockout and transgenic mice was investigated. On a ketogenic-diet (KD) that highlights capability of hepatic ketogenesis, Creb3l3(-/-) mice exhibited reduction of expression of genes for fatty oxidation and ketogenesis comparable to Ppara(-/-) mice. Most of the genes were further suppressed in double knockout mice indicating independent contribution of hepatic CREB3L3. During fasting, dependency of ketogenesis on CREB3L3 is lesser extents than Ppara(-/-) mice suggesting importance of adipose PPARalpha for supply of FFA and hyperlipidemia in Creb3l3(-/-) mice. In conclusion CREB3L3 plays a crucial role in hepatic adaptation to energy starvation via two pathways: direct related gene regulation and an auto-loop activation of PPARalpha. Furthermore, as KD-fed Creb3l3(-/-) mice exhibited severe fatty liver, activating inflammation, CREB3L3 could be a therapeutic target for NAFLD. |
