| First Author | Zhang X | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 346 |
| Issue | 4 | Pages | 1307-11 |
| PubMed ID | 16806075 | Mgi Jnum | J:110500 |
| Mgi Id | MGI:3640422 | Doi | 10.1016/j.bbrc.2006.06.042 |
| Citation | Zhang X, et al. (2006) Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation. Biochem Biophys Res Commun 346(4):1307-11 |
| abstractText | Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPARalpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPARalpha-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPARalpha dependence in the assay system. Surprisingly, a novel type of PPARalpha-independent peroxisome proliferation and enlargement was uncovered in PPARalpha-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11alpha, might be associated with the PPARalpha-independent peroxisome proliferation at least in part. |
