| First Author | Li XY | Year | 2010 |
| Journal | Science | Volume | 330 |
| Issue | 6009 | Pages | 1400-4 |
| PubMed ID | 21127255 | Mgi Jnum | J:167306 |
| Mgi Id | MGI:4867782 | Doi | 10.1126/science.1191792 |
| Citation | Li XY, et al. (2010) Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science 330(6009):1400-4 |
| abstractText | Synaptic plasticity is a key mechanism for chronic pain. It occurs at different levels of the central nervous system, including spinal cord and cortex. Studies have mainly focused on signaling proteins that trigger these plastic changes, whereas few have addressed the maintenance of plastic changes related to chronic pain. We found that protein kinase M zeta (PKMzeta) maintains pain-induced persistent changes in the mouse anterior cingulate cortex (ACC). Peripheral nerve injury caused activation of PKMzeta in the ACC, and inhibiting PKMzeta by a selective inhibitor, zeta-pseudosubstrate inhibitory peptide (ZIP), erased synaptic potentiation. Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMzeta in the ACC acts to maintain neuropathic pain. PKMzeta could thus be a new therapeutic target for treating chronic pain. |
