| First Author | Chan GC | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 43 | Pages | 9913-8 |
| PubMed ID | 16251439 | Mgi Jnum | J:123451 |
| Mgi Id | MGI:3718315 | Doi | 10.1523/JNEUROSCI.2376-05.2005 |
| Citation | Chan GC, et al. (2005) Hippocampal neurons express a calcineurin-activated adenylyl cyclase. J Neurosci 25(43):9913-8 |
| abstractText | Ca2+-stimulated adenylyl cyclases are important for several forms of neuroplasticity because they couple activity-dependent Ca2+ increases to cAMP in neurons. For example, the calmodulin-stimulated adenylyl cyclases, AC1 and AC8, are required for hippocampus-dependent memory and long-lasting long-term potentiation. To identify other mechanisms for Ca2+ stimulation of adenylyl cyclases, cultured hippocampal neurons from transgenic mice lacking both AC1 and AC8 [double knock-out (DKO) mice] were analyzed for Ca2+ stimulation of intracellular cAMP. Surprisingly, neurons from DKO mice showed significant Ca2+-stimulated cAMP accumulation that was blocked by inhibitors of calcineurin [PP2B (protein phosphatase 2B)], a Ca2+-activated protein phosphatase. Analysis of cultured neurons from calcineurin(-/-) mice confirmed that hippocampal neurons exhibit a calcineurin-dependent cAMP increase, which may contribute to some forms of neuroplasticity. |
