| First Author | Lee SM | Year | 2000 |
| Journal | Development | Volume | 127 |
| Issue | 3 | Pages | 457-67 |
| PubMed ID | 10631167 | Mgi Jnum | J:59283 |
| Mgi Id | MGI:1351292 | Doi | 10.1242/dev.127.3.457 |
| Citation | Lee SM, et al. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127(3):457-67 |
| abstractText | The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development. |
