| Primary Identifier | MGI:1857490 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Wnt1 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | The phenotype of homozygous mutant mice closely resembles that of Wnt1sw/Wnt1sw homozygotes (J:2964). Both are null mutations, and homozygotes for either are characterized by loss of the midbrain and adjacent components of the metencephalon. In null mutation homozygotes, the engrailed genes En1 and En2 are not expressed; this may be the mechanism by which the null mutation affects brain development (J:971). Expression of En-1 in the developing midbrain of Wnt-1-null embryos is sufficient to rescue early midbrain and anterior hindbrain development (J:35491). |
| molecularNote | Insertion of a neomycin resistance cassette into the second exon disrupted the Wnt1 gene. |
