Primary Identifier | MGI:1857689 | Allele Type | Transgenic |
Attribute String | Null/knockout, Reporter | Gene | Vcan |
Inheritance Mode | Recessive | Strain of Origin | C57BL/6J or CBA |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgene consisted of 3.5kb of the Hoxa1 regulatory region gene with a lacZ reporter sequence. The transgene inserted into intron 7 and separates exons 7 and 8, which code for the two chondroitin sulfate binding domains. RT-PCR analysis detected truncated mRNA transcripts in homozygous embryos. None of the alternative splice forms of the gene are detected in hearts from homozygous mice. |