| First Author | Walmsley MJ | Year | 2003 |
| Journal | Science | Volume | 302 |
| Issue | 5644 | Pages | 459-62 |
| PubMed ID | 14564011 | Mgi Jnum | J:86765 |
| Mgi Id | MGI:2682072 | Doi | 10.1126/science.1089709 |
| Citation | Walmsley MJ, et al. (2003) Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302(5644):459-62 |
| abstractText | The Rac1 guanosine triphosphatase (GTPase) has been implicated in multiple cellular functions, including actin dynamics, proliferation, apoptosis, adhesion, and migration resulting from signaling by multiple receptors, including the B cell antigen receptor (BCR). We used conditional gene targeting to generate mice with specific Rac1 deficiency in the B cell lineage. In the absence of both Rac1 and the highly related Rac2, B cell development was almost completely blocked. Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance. |
