| First Author | Gamer LW | Year | 2011 |
| Journal | Genesis | Volume | 49 |
| Issue | 9 | Pages | 719-24 |
| PubMed ID | 21538804 | Mgi Jnum | J:175737 |
| Mgi Id | MGI:5287098 | Doi | 10.1002/dvg.20761 |
| Citation | Gamer LW, et al. (2011) BMPR-II is dispensable for formation of the limb skeleton. Genesis 49(9):719-24 |
| abstractText | Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and for activin-like ligands whereas BMPR-II functions only as a BMP receptor. As BMP signaling is required for endochondral ossification and loss of either Acvr2a or Acvr2b is not associated with deficits in limb development, we hypothesized that BMPR-II would be essential for BMP signaling during skeletogenesis. We removed BMPR-II from early limb mesoderm by crossing BMPR-II floxed mice with those carrying the Prx1-Cre transgene. Mice lacking limb expression of BMPR-II have normal skeletons that could not be distinguished from control littermates. From these data, we conclude that BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b. genesis, 00:1-6, 2011. (c) 2011 Wiley-Liss, Inc. |
