| First Author | Koutsioumpa C | Year | 2023 |
| Journal | Dev Cell | Volume | 58 |
| Issue | 20 | Pages | 2032-2047.e6 |
| PubMed ID | 37607547 | Mgi Jnum | J:342051 |
| Mgi Id | MGI:7544802 | Doi | 10.1016/j.devcel.2023.07.020 |
| Citation | Koutsioumpa C, et al. (2023) Skin-type-dependent development of murine mechanosensory neurons. Dev Cell 58(20):2032-2047.e6 |
| abstractText | Mechanosensory neurons innervating the skin underlie our sense of touch. Fast-conducting, rapidly adapting mechanoreceptors innervating glabrous (non-hairy) skin form Meissner corpuscles, while in hairy skin, they associate with hair follicles, forming longitudinal lanceolate endings. How mechanoreceptors develop axonal endings appropriate for their skin targets is unknown. We report that mechanoreceptor morphologies across different skin regions are indistinguishable during early development but diverge post-natally, in parallel with skin maturation. Neurons terminating along the glabrous and hairy skin border exhibit hybrid morphologies, forming both Meissner corpuscles and lanceolate endings. Additionally, molecular profiles of neonatal glabrous and hairy skin-innervating neurons largely overlap. In mouse mutants with ectopic glabrous skin, mechanosensory neurons form end-organs appropriate for the altered skin type. Finally, BMP5 and BMP7 are enriched in glabrous skin, and signaling through type I bone morphogenetic protein (BMP) receptors in neurons is critical for Meissner corpuscle morphology. Thus, mechanoreceptor morphogenesis is flexibly instructed by target tissues. |
