| Primary Identifier | MGI:1857718 | Allele Type | Spontaneous |
| Gene | Tlr4 | Inheritance Mode | Codominant |
| Strain of Origin | C3H/HeJ | Is Recombinase | false |
| Is Wild Type | false |
| description | C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4lps-n allele; others, including Tlr4Lps-d, show codominance. Genbank ID for this allele: AF095353 |
| molecularNote | This allele corresponds to a mutation in the third exon of the gene. A C-to-A substitution at coding tide position 2135 (c.2135C>A) results in an amino acid substitution that replaces proline with histidine at position 712 (p.P712H). |
