| First Author | Herter S | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 2 | Pages | 891-8 |
| PubMed ID | 16002687 | Mgi Jnum | J:100719 |
| Mgi Id | MGI:3589338 | Doi | 10.4049/jimmunol.175.2.891 |
| Citation | Herter S, et al. (2005) Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol 175(2):891-8 |
| abstractText | Influenza virus infection induces maturation of murine dendritic cells (DCs), which is most important for the initiation of an immune response. However, in contrast to EL-4 and MC57 cells, DCs present viral CTL epitopes with a delay of up to 10 h. This delay in Ag presentation coincides with the up-regulation of MHC class I molecules as well as costimulatory molecules on the cell surface and the accumulation of newly synthesized ubiquitinated proteins in large cytosolic structures, called DC aggresome-like-induced structures (DALIS). These structures were observed previously after LPS-induced maturation of DCs, and it was speculated that they play a role in the regulation of MHC class I Ag presentation. Our findings provide the first evidence for a connection between DC maturation, MHC class I-restricted Ag presentation, and DALIS formation, which is further supported by the observation that DALIS contain ubiquitinated influenza nucleoprotein. |
