First Author | Reibaud M | Year | 1999 |
Journal | Eur J Pharmacol | Volume | 379 |
Issue | 1 | Pages | R1-2 |
PubMed ID | 10499380 | Mgi Jnum | J:102556 |
Mgi Id | MGI:3607755 | Doi | 10.1016/s0014-2999(99)00496-3 |
Citation | Reibaud M, et al. (1999) Enhancement of memory in cannabinoid CB1 receptor knock-out mice. Eur J Pharmacol 379(1):R1-2 |
abstractText | We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB receptors play a crucial role in the process of memory storage and retrieval. |